XI. Fluids and Electrolytes

       A. Should the overnight deficit be replaced?
          (hourly fluid maintenence x hours N.P.O.)

            1. Probably not.

            2. Exceptions include patients undergoing
               carotid artery repair, aneurysm repairs
               and patients with stenotic valvular
               lesions such as aortic stenosis.

	    3. Also consider replacement if there are
	       clinical signs of hypovolemia, such as
	       a sagging BP in the face of what seems
	       to be inadequate anesthesia, an a-line 
	       tracing baseline that varies with 
	       respiration, falling urine output, etc.

	    4. Remember, it is better to run these pts.
	       dry, as a lower vascular volume often 
	       helps to maintain a lower brain volume.
	       Remember the axiom: "If it isn't broken,
	       don't fix it!"

       B. Urinout output should be replaced cc for cc?


       C. Which crystalloid should be used?

            1. The main factor governing fluid movement
               into and out of the brain is osmolality.
               Fluids should therefore be as isotonic as
               possible. Ringers has an osmolality of
               273, making it the most hypotonic of the
               crystalloids normally used. Plasmalyte
               (295) and Normal Saline (308) are better
               choices. 

       D. When should colloid be used?

            1. Unless otherwise indicated, I start
               limiting crystalloid and giving primarily
               colloid after 2 to 3 liters of the former.

            2. Labile blood pressures at induction in a
               known hypertensive patient often means
               that the patient is hypovolemic.  Colloid
               is a good choice here.  

       E. When should blood loss be treated?

            1. Put the suction cannisters where you can
               easily touch them from the anesthesia
               machine. Remember that a plastic drape
               with a pouch in the bottom may be placed
               around the head. Get up frequently and
               walk around the OR table to assess blood
               loss. Write down a number for EBL on the
               OR record no matter how wild a guess it
               is. 

            2. This has to be individualized to the
               patient. Aneurysm patients, with their
               propensity for vasospasm, should be more
               aggresively transfused. Some neurosurgeons
               do not want the Hct to fall below 30. 

            3. The fluid restriction and forced diuresis
               that occurs in neuroanesthesia may cause
               the Hct to remain stable or even rise in
               the face of anemia.  Consider this when
               hemodynamic instability and increasing
               lactate levels occur.

       F. How can you judge if blood volume is low?

            1. Maintain strict I&O records.

            2. Lactate levels. A normal lactate is 1. A
               rising lactate may indicate hypoperfusion.
               

            3. Variation of blood pressure with
               ventilation greater than 10 mm Hg.

            4. CVP

                 a. A normal CVP is 4 to 8. 

                 b. The CVP is usually employed as a trend
                    indicator to be considered with all
                    the other indicators. It is usually
                    not necessary to automatically give
                    fluid to maintain a given CVP but
                    strong consideration should be given
                    to doing so.

                     (1) The patient in the sitting
                         position will require maintenance
                         of the CVP to reduce risk of air
                         embolism.

                     (2) Aneurysm patients need their CVP
                         maintained.    

                 c. The CVP is exquisitly sensitive to
                    transducer height. Before making a
                    change in table height or table
                    rotation, glance at the CVP. Then make
                    the table adjustment and a subsequent
                    adjustment to transducer height so
                    that CVP is the same as before the
                    table turn. Putting the patient in
                    Trendelenburgh establishes a new
                    value. Mark the OR record as to the
                    change in head up or down. If the CVP
                    takes a sudden jump, think about a
                    change in Trendelenburgh. 

            5. Urine output

                 a. If there is no urine output after 
 		    mannitol, suspect a kink in the Foley
                    catheter.

            6. A rising serum Na: consider SIADH

            7. Changes in HCT. A Hct that is constant in
               the face of continuing blood loss
               indicates a possible the need for fluids.
               Another possibility is that the patient
               was overhydrated earlier.  

            8. Excessive response to vasodilators

            9. Hypoxemia, tachycardia, hypotension

           10. Measuring the serum osmolality may assist
               in fluid balance. However, after mannitol
               is given, these numbers may not mean much.
               

       G. Blood glucose

            1. Glucose is kept under control in
               neuroanesthesia.

            2. Patients on steroids, as well as known
               diabetics may have elevated glucose.

                 a. Treat with 5-10 units boluses of IV
                    regular insulin at 30-45 min intervals
                    with a goal of serum glucose under
                    200.

       H. Potassium

            1. Hypokalemia is a strong possibility when
               forced diuresis is employed. It is not always 
	       necessary to replace K+ when it is > 3.0.
	       Except when more losses are anticipated, the 
	       kidneys do a very good job of adjusting the balance.
	       Strict replacement is important in certain
	       patients, such as those taking digoxin.

Brain Protection