Facultad de Ciencias

Lineas de investigación

• My interest encompass the application of single-molecule techniques for material science and soft matter. Specifically, the use of Atomic Force Microscopy, either by its own or in combination with fluorescence microscopy, for studying both natural and artificial protein nanocages in liquid. On one hand, I am interested in studying the structure-function-properties interplay of individual viruses. On the other hand, my interests include the investigation of the physicochemical properties of protein shells utilized as nanocontainers for alien molecules, such as proteins, enzymes, metals, etc.

1. Tuning Viral Capsid Nanoparticle Stability with Symmetrical Morphogenesis, Aida Llauró, Benjamin Schwarz, Ranjit Koliyatt, Pedro J. de Pablo, and Trevor Douglas, ACS Nano, 10 (9), pp 8465–8473, (2016). [URL]

2. Mechanics of Viral Chromatin Reveals the Pressurization of Human Adenovirus, A. Ortega-Esteban, G. Condezo, A. J. Pérez-Berná, M. Chillón, S. J. Flint, D. Reguera, C. San Martín and P. J. de Pablo, ACS Nano, 9 (11), pp 10826–10833, (2015). [URL]

3. Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses, A. Ortega-Esteban, K. Bodensiek, C. San Martín, M. Suomalainen, U. Greber, Pedro J. de Pablo and I. A. T. Schaap, ACS Nano, 9 (11), pp 10571–10579, (2015). [URL]

4. Quantitative nanoscale electrostatics of viruses, M. Hernando-Pérez, A. X. Cartagena-Rivera, A. Lošdorfer Božič, P. J. P. Carrillo, C. San Martín, M. G. Mateu, A. Raman, R. Podgornik and P. J. de Pablo, Nanoscale 7(41): 17289-17298, (2015). [URL]

5. Cementing proteins provide extra mechanical stabilization to viral cages, M. Hernando-Pérez, S. Lambert, E. Nakatani-Webster, C. E. Catalano & P. J. de Pablo, Nature Communications 5, 4520 (2014). [URL]

6. Mechanical elasticity as a physical signature of conformational dynamics in a virus particle, Milagros Castellanos, Rebeca Pérez, Carolina Carrasco, Mercedes Hernando-Pérez, Julio Gómez-Herrero, Pedro J. de Pablo, and Mauricio G. Mateu, Proceedings of the National Academy of Sciences of the United States of America 109(30): 12028-12033, (2012). [URL]

7. The capillarity of nanometric water menisci confined inside closed-geometry viral cages, C. Carrasco, M. Douas, R. Miranda, M. Castellanos, P. A. Serena, J. L. Carrascosa, M. G. Mateu, M. I. Marquésc and P. J. de Pablo, Proceedings of the National Academy of Sciences of the United States of America 106(14): 5475-5480, (2009). [URL]

8. Manipulation of the mechanical properties of a virus by protein engineering, Carolina Carrasco, Milagros Castellanos, Pedro J. de Pablo, and Mauricio G. Mateu, Proceedings of the National Academy of Sciences of the United States of America 105(11): 4150-4155, (2008). [URL]

9. DNA-mediated anisotropic mechanical reinforcement of a virus, C. Carrasco, A. Carreira, I. A. T. Schaap, P. A. Serena, J. Gómez-Herrero, M. G. Mateu, and P. J. de Pablo, Proceedings of the National Academy of Sciences of the United States of America 103(37): 13706-13711, (2006). [URL]

10. Bacteriophage capsids: Tough nanoshells with complex elastic properties, I. L. Ivanovska, P. J. de Pablo, B. Ibarra, G. Sgalari, F. C. MacKintosh, J. L. Carrascosa, C. F. Schmidt, and G. J. L. Wuite, Proceedings of the National Academy of Sciences of the United States of America 101(20): 7600-7605, (2004). [URL]

Otra información de interés

ID de investigador / Código ORCID 

- researcherid.com/rid/L-9392-2014 / orcid.org/0000-0003-2386-3186