Science Faculty

A General Asymmetric Formal Synthesis of Aza-Baylis–Hillman Type Products under Bifunctional Catalysis

Author/s

Frías, M.; Carrasco, A. C.; Fraile, A.; Alemán, J.

Año de edición

2018

Referencia completa

Chem. Eur. J. 2018, 24, 3117 – 3121. DOI: 10.1002/chem.201705218.

Resumen

A new organocatalytic strategy for the synthesis of enantioenriched aza-Baylis–Hillman type products via a frustrated vinylogous reaction is presented. This process proceeds under mild conditions with good yields, completed Z/E selectivity and excellent enantioselectivities. Moreover, easy derivatizations of the final products led to important building blocks of organic synthesis such as 1,3-aminoalcohols and Lewis base catalysts.

Otros datos de interés

Destacada por Chem. Eur. J. como “Cover Picture” 2018, 24 (13).