Role of nuclear receptors in homeostasis, regeneration and repair

Línea de investigación

Nuclear Receptor Signaling.

Descripción

Cardiomyocytes are considered as quiescent cells with limited capacity to proliferate, which highly restricts the regenerative ability of the mammalian heart upon injury. Growing evidences suggest that the modulation of cardiac metabolic environment and the activation of the immune system may be good candidates for triggering tissue repair. In this project, we aim to characterize the transcriptional and epigenomic mechanisms control by nuclear receptors that drive cardiac homeostasis and regeneration after myocardial infarction, decoding the functional impact of metabolism and macrophage-driven inflammatory signals. We will use tissue-specific knockouts, transcriptomics, epigenomics and in vivo imaging to unravel the role of nuclear receptors in heart regeneration. Some prior knowledge of R and/or Python programming will be valued.

More information at: Nuclear Receptor Signaling Lab.

Contacto

María Mercedes Ricote Pacheco.

Correo electrónico: mricote@cnic.es.