Immune and Inflammatory Diseases.
A number of key nodes regulating innate immunity and inflammation localize to the early secretory compartment and require trafficking across the secretory apparatus to be activated. A good example is the cGAS/STING system and downstream signalling networks, essential in innate immunity defense and, upon dysregulation, in aging and tissue homeostasis. We aim to explore these emerging dynamic links between cell secretion and inflammation, as they potentially hold a key to how cells and tissues trigger alert signals upon damage, and coordinate them with repair and regeneration or scarring. The TFM project is focused on a novel dual regulator we identified through genome-scale functional screens, that couples both processes. In this project we will use state-of-the-art cell biology and microscopy, proteomics and anatomopathology from in vivo models, to characterize the role of this new regulator and its potential relevance for tissue repair.
Miguel Sánchez Álvarez.
Correo electrónico: msalvarez@iib.uam.es.
Facultad de Medicina. Universidad Autónoma de Madrid. Calle del Arzobispo Morcillo 4. 28029 Madrid. Tel.: +34 914 975 486. Correo electrónico: informacion.medicina@uam.es
